Innovation is Urgently Needed in Neurology and Rare Disease

We’ve built a capital efficient precision discovery platform based in the real world

We’ve developed molecularly barcoded substrates that record the functional activity of targets

We discover small molecule therapeutics 10X faster and 50X cheaper with 15X fewer scientists and a 40X smaller lab footprint

Measure target activity and function for millions of compounds in one tube

  • Directly measure physiological function of targets

  • High accuracy, Low variability

  • Low cost: Inexpensive libraries, no live cells needed, small footprint, 1-2 scientists

  • Timing: Weeks

Series of targets in development in platform

Data Room

Screening for target #1 in rare neurodegenerative condition

  • Platform established for first target

  • Precise functional readouts

    • High accuracy

    • Very scalable

    • Low variation

  • Intra assay coefficient of variation < .03

  • Inter assay coefficient of variation < .04

  • Tunable response window

Target-specific assays and substrate-specific molecular barcoding

All performed in-house at Seq

  • Molecular barcoding of substrates

  • Small molecule screening assays

  • Sequencing & Analytics

Raw Small Molecule Screening and Calibration

Highly reactive compounds - 320 compound PAINS deck

First pass potentiator hit rate = .78%
First pass inhibitor hit rate = .52% 

Control Plate Example

Coefficient of variation less than .03

Low Variation Across Individual Bait Readouts (Subsampled)